Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists

…, LL Froelich, DM Gapinski, BE Mallett…

Index: Jackson, William T.; Boyd, Robert J.; Froelich, Larry L.; Gapinski, D. Mark; Mallett, Barbara E.; Sawyer, J. Scott Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1726 - 1734

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Citation Number: 56

Abstract

In an effort to develop increasingly potent and specific leukotriene B4 (LTB4) receptor antagonists, several xanthone dicarboxylic acids were synthesized and evaluated. Two separate synthetic routes were used to construct a xanthone nucleus containing a regiospecific orientation of each carboxylic acid pharmacophore. These compounds represent the major conformationally-restricted analogues of benzophenone dicarboxylic ...