Synthesis and antibacterial activity of 1, 3-diaryl-4-cyanopyrazoles

O Prakash, R Pundeer, P Ranjan…

Index: Prakash, Om; Pundeer, Rashmi; Ranjan, Pooja; Pannu, Kamaljeet; Dhingra, Yogita; Aneja Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 4 p. 563 - 568

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Citation Number: 17

Abstract

Abstract: A mild, short and simple method for the small scale synthesis of pharmaceutically important 1, 3-diaryl-4-cyanopyrazoles 3 is reported from acetophenone arylhydrazones 1 through a two step reaction. All the title compounds have been subjected to in vitro antibacterial testing against four pathogenic strains namely, S. aureus, B. subtilis (gram positive) and gram negative bacteria namely, P. aeruginosa and E. coli. Preliminary ...

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