Carbocationic species (High Energy Intermediates) have been postulated as intermediates in the course of enzymatic synthesis of ergosterol. Protonated aza-analogues of the sterol are thus potential inhibitors. The synthesis of substituted quinolizidines (3) is reported. 4- Methoxy-2, 3-dimethylpyridine (4) was metalated and reacted with substituted 3- chloropropanal to build the 1-methyl-2-quinolizidinone. The lateral chain was prepared ...
