Spirocyclic nonpeptide glycoprotein IIb–IIIa antagonists. Part 2: design of potent antagonists containing the 3-azaspiro [5.5] undec-9-yl template

…, MM Mehrotra, J Heath, G Ruhter, T Schotten…

Index: Pandey; Seroogy; Volkots; Smyth; Rose; Mehrotra; Heath; Ruhter; Schotten; Scarborough Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1293 - 1296

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Citation Number: 11

Abstract

The synthesis and biological activity of novel glycoprotein IIb–IIIa anatagonists containing 3- azaspiro [5.5] undec-9-yl nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the monoazaspirocyclic structure as central template for nonpeptide RGD mimics.