2, 4-Dimethoxyphenylsemicarbazones with anticonvulsant activity against three animal models of seizures: Synthesis and pharmacological evaluation

R Thirumurugan, D Sriram, A Saxena, J Stables…

Index: Thirumurugan, Rathinasabapathy; Sriram, Dharmarajan; Saxena, Amrita; Stables, James; Yogeeswari, Perumal Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 9 p. 3106 - 3112

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Citation Number: 81

Abstract

Various 2, 4-dimethoxyphenylsemicarbazones were synthesized starting from 2, 4- dimethoxyaniline via a phenylcarbamate intermediate. The structures were confirmed by spectral and elemental analyses. The anticonvulsant activity of the synthesized compounds was established after intraperitoneal administration in three seizure models in mice which include maximal electroshock seizure, subcutaneous pentylenetetrazole, and ...