Aromatic radiofluorination and biological evaluation of 2-aryl-6-[18 F] fluorobenzothiazoles as a potential positron emission tomography imaging probe for β-amyloid …

…, HS Park, BS Moon, JH Jung, JM Jeong, SE Kim

Index: Lee, Byung Chul; Kim, Ji Sun; Kim, Bom Sahn; Son, Ji Yeon; Hong, Soo Kyung; Park, Hyun Soo; Moon, Byung Seok; Jung, Jae Ho; Jeong, Jae Min; Kim, Sang Eun Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 9 p. 2980 - 2990

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Citation Number: 20

Abstract

Abstract To develop agents for radionuclide imaging Aβ plaques in vivo, we prepared three fluorine-substituted analogs of arylbenzothiazole class; compound 2 has a high affinity for Aβ (K i= 5.5 nM) and the specific binding to Aβ in fluorescent staining. In preparation for ...