Abstract To develop a parenteral solution of relatively water-insoluble metronidazole (2- methyl-5-nitro-1H-imidazole-1-ethanol), its phosphate ester was synthesized via two routes. One route utilized 2-cyanoethyl phosphate and the other utilized pyrophosphoryl tetrachloride. The first method used dicyclohexylcarbodiimide as a coupling agent and the cy-anoethyl group was removed under mild alkaline conditions. The second method was ...
