A practical synthesis of the platelet fibrinogen antagonist, elarofiban

JH Cohen, ME Bos, S Cesco-Cancian…

Index: Cohen, Judith H.; Roessler, Armin; Scott, Lorraine; Sorgi, Kirk L.; Villani Jr., Frank J.; Webster, Robin R. H.; Weh, Christian; Bos, Mary Ellen; Cesco-Cancian, Sergio; Harris, Bruce D.; Hortenstine, John T.; Justus, Michael; Maryanoff, Cynthia A.; Mills, John; Muller, Stefan Organic Process Research and Development, 2003 , vol. 7, # 6 p. 866 - 872

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Citation Number: 14

Abstract

Elarofiban is a novel, nonpeptide, orally active fibrinogen receptor antagonist useful for the treatment of platelet mediated thrombotic disorders (Costanzo, MJ; Hoekstra, WJ; Maryanoff, BE WO, 97/41102, 1997). Herein we describe the process research that was carried out for the synthesis of elarofiban that eventually led to the development of a safe and cost-effective commercial scale process.