The design of agents to control DNA methylation adducts. Enhanced major groove methylation of DNA by an N-methyl-N-nitrosourea functionalized phenyl neutral red …

P Mehta, K Church, J Williams, FX Chen…

Index: Mehta, Pratibha; Church, Kevin; Williams, Jonathan; Chen, Fa-Xian; Encell, Lance; Shuker, David E.G.; Gold, Barry Chemical Research in Toxicology, 1996 , vol. 9, # 6 p. 939 - 948

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Citation Number: 13

Abstract

An N-methyl-N-nitrosourea (MNU) moiety [CH3N (NO) C (O) NH-] linked to the C4'-position of the 5-substituted phenyl ring of phenyl neutral red (PNR), 2-methyl-3-amino-5-[p-[[2-[(N- nitroso-N-methylcarbamoyl) amino] ethyl] carbamoyl] phenyl]-7-(dimethylamino) phenazenium chloride (MNU-PNR), has been synthesized as an approach to design a molecule that will deliver alkylating agents with some preference to guanine (Gua) in the ...