The use of p-alanine ester in the synthesis and" partial synthesis" of pantothenic acida has made desirable a rapid and convenient method for the preparation of that substance. Because of the instability of the free ester, 4 quantities of the material cannot be kept on hand, and must be made up immediately before use. We have found the preparation of the ester from the ester hydrochloride to be inconvenient and the yields poor. Kuhn and ...