Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

…, PG Pollard, IK Sebhat, J Liu, L Guo, DE Cashen…

Index: Hong, Qingmei; Bakshi, Raman K.; Palucki, Brenda L.; Park, Min K.; Ye, Zhixiong; He, Shuwen; Pollard, Patrick G.; Sebhat, Iyassu K.; Liu, Jian; Guo, Liangqin; Cashen, Doreen E.; Martin, William J.; Weinberg, David H.; MacNeil, Tanya; Tang, Rui; Tamvakopoulos, Constantin; Peng, Qianping; Miller, Randy R.; Stearns, Ralph A.; Chen, Howard Y.; Chen, Airu S.; Strack, Alison M.; Fong, Tung M.; MacIntyre, D. Euan; Wyvratt, Matthew J.; Nargund, Ravi P. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2330 - 2334

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Citation Number: 9

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models. ... We report the discovery of piperazine urea based ...