Further exploration of 1-{2-[bis-(4-fluorophenyl) methoxy] ethyl} piperazine (GBR 12909): Role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl …

D Lewis, Y Zhang, T Prisinzano, CM Dersch…

Index: Lewis, David; Zhang, Ying; Prisinzano, Thomas; Dersch, Christina M.; Rothman, Richard B.; Jacobson, Arthur E.; Rice, Kenner C. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 7 p. 1385 - 1389

Full Text: HTML

Citation Number: 12

Abstract

A series of N-aromatic, N-heteroaromatic, and oxygenated N-phenylpropyl derivatives of 1- (2-benzhydryloxyethyl)-piperazine and 1-{2-[bis-(4-fluorophenyl) methoxy] ethyl} piperazine, analogues of GBR 12909 (1a) and 12935 (1b), was synthesized and examined for their dopamine (DAT) and serotonin (SERT) transporter binding properties. One of these compounds, racemic 3-[4-(2-benzhydryloxyethyl) piperazin-1-yl]-1-(3-fluorophenyl)- ...