Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors

M Forghieri, C Laggner, P Paoli, T Langer…

Index: Forghieri, Marco; Laggner, Christian; Paoli, Paolo; Langer, Thierry; Manao, Giampaolo; Camici, Guido; Bondioli, Lucia; Prati, Fabio; Costantino, Luca Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 7 p. 2658 - 2672

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Citation Number: 28

Abstract

Protein tyrosine phosphatases (PTP) are crucial elements in eukaryotic signal transduction. Several reports suggested that the LMW-PTP family has oncogenic relevance. Moreover, LMW-PTP has been recognized as a negative regulator of insulin-mediated mitotic and metabolic signaling. Thus, inhibition of the LMW-PTP can be considered an attractive approach for the design of new therapeutic agents for the treatment of type II diabetes and ...