The base. and cholinesterase-caralyzed hydrolyses of the following optically active analogs of acetylcholine were studied:? da)-trimethvlamrnonium-2 (ai-acetoxy-trans-decalin iodide. threo-and t~~ thro-ci, d-dimethylacetylcholine iodide, u-methylacetylcholine. and 3- methylacetylcholine. Evidence that the optimum dihedral-5-CC-0 angle in the transition state for acetylcholinesterase hydrolysis of acetylcholine analogs is positive and anticlinal is ...
