Total Synthesis of the Sesterterpenoid (t)-Palauolide ... Edward Piers* and John SM Wai Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T I Y6 ... Transformation of 3,6-dimethylcyclohex-2-enone (2) into the sesterterpenoid (+)-palauolide (I) ... Palauolide, a structurally unique antimicrobial sesterterpe- noid isolated from a mixture of sponges collected from Palau, Western Caroline Islands, has been shown previously1 ...