Modular synthesis of heparin oligosaccharides

HA Orgueira, A Bartolozzi, P Schell…

Index: Orgueira, Hernan A.; Bartolozzi, Alessandra; Schell, Peter; Litjens, Remy E. J. N.; Palmacci, Emma R.; Seeberger, Peter H. Chemistry - A European Journal, 2003 , vol. 9, # 1 p. 140 - 169

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Citation Number: 195

Abstract

Abstract A general, modular strategy for the first completely stereoselective synthesis of defined heparin oligosaccharides is described. Six monosaccharide building blocks (four differentially protected glucosamines, one glucuronic and one iduronic acid) were utilized to prepare di-and trisaccharide modules in a fully selective fashion. Installation of the α- glucosamine linkage was controlled by placing a conformational constraint on the uronic ...