Derivatisation of microcystin with a redox-active label for high-performance liquid chromatography/electrochemical detection

…, DCM Ng, JSY Lau, RSS Wu, PKS Lam

Index: Lo, Kenneth Kam-Wing; Ng, Dominic Chun-Ming; Lau, Jason Shing-Yip; Wu, Rudolf Shiu-Sun; Lam, Paul Kwan-Sing New Journal of Chemistry, 2003 , vol. 27, # 2 p. 274 - 279

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Citation Number: 13

Abstract

Microcystins are a group of low molecular weight, cyclic peptide hepatotoxins. The most common detection and quantitation methods for these toxins are liquid chromatography with UV or mass spectrometric detections, phosphatase inhibition assays and enzyme-linked immunosorbent assays. In addition, derivatisation of these toxins with organic fluorophores followed by CE/laser induced fluorescence detection and HPLC/chemiluminescence ...