Rh??catalyzed highly enantioselective synthesis of 3??arylbutanoic acids

…, L Zhou, CJ Wang, X Zhang

Index: Sun, Xianfeng; Zhou, Le; Wang, Chun-Jiang; Zhang, Xumu Angewandte Chemie - International Edition, 2007 , vol. 46, # 15 p. 2623 - 2626

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Citation Number: 35

Abstract

Enantiomerically pure 3-arylbutanoic acids and their derivatives such as chiral 3- arylbutanols are important intermediates for the synthesis of aromatic sesquiterpenes of the bisabolane family [1] and useful building blocks in organic synthesis.[2, 3a] A variety of asymmetric syntheses of the carboxylic acids have therefore been developed, such as 1, 4- addition of organometallic reagents to chiral a, b-unsaturated esters and amides,[3] ...