Diheteropeptin, a New Substance with TGF-. BETA.-like Activity, Produced by a Fungus, Diheterospora chlamydosporia. I. Production, Isolation and Biological …

…, K Nagai, KI Suzuki, Y Hayakawa, H Seto

Index: Masuoka; Shin-ya; Furihata; Matsumoto; Takebayashi; Nagai; Suzuki; Hayakawa; Seto Journal of Antibiotics, 2000 , vol. 53, # 8 p. 793 - 798

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Citation Number: 19

Abstract

A new metabolite, diheteropeptin, was found in the culture broth of Diheterospora chlamydosporia Q58044 by screening for TGF-β-like active substances. Diheteropeptin was extracted from the culture supernatant and purified by a series of chromatographies such as silica gel, gel filtration and HPLC. Diheteropeptin exhibited cytostatic activity in MvlLu cells with an IC 50 value of 20.3 μM and inhibited histone deacetylase.

Design, synthesis, potency, and cytoselectivity of anticance...

[Kahnberg, Pia; Lucke, Andrew J.; Glenn, Matthew P.; Boyle, Glen M.; Tyndall, Joel D. A.; Parsons, Peter G.; Fairlie, David P. Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7611 - 7622]

Synthesis of DL-α-aminosuberic acid and its optical resoluti...

[Hase,S. et al. Bulletin of the Chemical Society of Japan, 1968 , vol. 41, p. 1266 - 1267]