Journal of medicinal chemistry

The synthesis of N-hydroxy-N'-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells

JC Stowell, RI Huot, L Van Voast

Index: Stowell, John C.; Huot, Rachel I.; Voast, Lainie Van Journal of Medicinal Chemistry, 1995 , vol. 38, # 8 p. 1411 - 1413

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Citation Number: 56

Abstract

We have developed a practical synthesis of N-hydroxy-N'-phenyloctanediamide from the methyl ester of suberanilic acid. It provides the product in high yield and purity with a simple purification process. We have found that at M it has a dramatic effect on T/5 AXC/SSh rat prostate cancer cells in vitro. It is a potent inhibitor of cell proliferation and it changes the cell morphology to resemble nonmalignant cells.

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Discovery of (2 E)-3-{2-butyl-1-[2-(diethylamino) ethyl]-1 H...

[Wang, Haishan; Yu, Niefang; Chen, Dizhong; Lee, Ken Chi Lik; Lye, Pek Ling; Chang, Joyce Wei Wei; Deng, Weiping; Ng, Melvin Chi Yeh; Lu, Ting; Khoo, Mui Ling; Poulsen, Anders; Sangthongpitag, Kanda; Wu, Xiaofeng; Hu, Changyong; Goh, Kee Chuan; Wang, Xukun; Fang, Lijuan; Goh, Kay Lin; Khng, Hwee Hoon; Goh, Siok Kun; Yeo, Pauline; Liu, Xin; Bonday, Zahid; Wood, Jeanette M.; Dymock, Brian W.; Kantharaj, Ethirajulu; Sun, Eric T. Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4694 - 4720]