Penetration enhancers mediate trans-dermal drug delivery. The penetration enhancer dodecyl-azacycloheptanone (Azone®) was characterized in situ with 2H NMR on human stratum corneum treated with either uniformly deuterated Azone® or penetration enhancer with only the entire chain deuterated, in both cases in propylene glycol. The 2H NMR spectrum at ambient temperature constitutes a single narrow line only 180 Hz wide. This ...
