Structure–Activity Relationships of Lysophosphatidylserine Analogs as Agonists of G-Protein-Coupled Receptors GPR34, P2Y10, and GPR174

…, K Kano, K Makide, J Aoki, T Ohwada

Index: Iwashita, Masazumi; Makide, Kumiko; Nonomura, Taro; Misumi, Yoshimasa; Otani, Yuko; Ishida, Mayuko; Taguchi, Ryo; Tsujimoto, Masafumi; Aoki, Junken; Arai, Hiroyuki; Ohwada, Tomohiko Journal of Medicinal Chemistry, 2009 , vol. 52, # 19 p. 5837 - 5863

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Citation Number: 10

Abstract

Lysophosphatidylserine (LysoPS) is an endogenous lipid mediator generated by hydrolysis of membrane phospholipid phosphatidylserine. Recent ligand screening of orphan G- protein-coupled receptors (GPCRs) identified two LysoPS-specific human GPCRs, namely, P2Y10 (LPS2) and GPR174 (LPS3), which, together with previously reported GPR34 (LPS1), comprise a LysoPS receptor family. Herein, we examined the structure–activity ...