Journal of medicinal chemistry

Dopamine autoreceptor agonists: resolution and pharmacological activity of 2, 6-diaminotetrahydrobenzothiazole and an aminothiazole analog of apomorphine

CS Schneider, J Mierau

Index: Schneider, Claus S.; Mierau, Joachim Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 494 - 498

Full Text: HTML

Citation Number: 114

Abstract

The enantiomers of the aminothiazole analogues of the known dopaminergic agonists apomorphine (1) and 2-aminohydroxytetralin (2) have been prepared. The absolute configurations of the enantiomers of 2, g-diaminotetrahydrobenzothiazole have been established by X-ray crystallographic analysis. Dopamine (DA) autoreceptor agonist activities of the compounds were evaluated. Testing revealed (-)-5, the S enantiomer, to ...