Synthesis and exploration of novel curcumin analogues as anti-malarial agents

S Mishra, K Karmodiya, N Surolia, A Surolia

Index: Mishra, Satyendra; Karmodiya, Krishanpal; Surolia, Namita; Surolia, Avadhesha Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 6 p. 2894 - 2902

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Citation Number: 118

Abstract

Curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anti-cancer activities. Recent studies have indicated that curcumin inhibits chloroquine-sensitive (CQ-S) and chloroquine-resistant (CQ-R) Plasmodium falciparum growth in culture with an IC50 of∼ 3.25 μM (MIC= 13.2 μM) and IC50 4.21 μM (MIC= 14.4 μM), respectively. In order to expand their potential as anti- ...