In order to establish the structural requirements for binding to the brain cannabinoid receptor (CB1), we have synthesized numerous fatty acid amides, ethanolamides, and some related simple derivatives and have determined their K i values. A few α-methyl-or α, α- dimethylarachidonoylalkylamides were also examined. In the 20: 4, n-6 series, the unsubstituted amide is inactive; N-monoalkylation, at least up to a branched pentyl group, ...
