Reactivity toward thiols and cytotoxicity of 3-methylene-2-oxindoles, cytotoxins from indole-3-acetic acids, on activation by peroxidases

LK Folkes, S Rossiter, P Wardman

Index: Folkes, Lisa K.; Rossiter, Sharon; Wardman, Peter Chemical Research in Toxicology, 2002 , vol. 15, # 6 p. 877 - 882

Full Text: HTML

Citation Number: 15

Abstract

Oxidation of indole-3-acetic acid and its derivatives by peroxidases such as that from horseradish produces many products, including 3-methylene-2-oxindoles. These have long been associated with biological activity, but their reactivity has not been characterized. We have previously demonstrated the potential value of substituted indole acetic acids and horseradish peroxidase as the basis for targeted cancer therapy, since the compounds ...