Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

…, S Poondru, ME Theoclitou, B Tyurin, MJ Zinda

Index: Scott, David A.; Balliet, Carrie L.; Cook, Donald J.; Davies, Audrey M.; Gero, Thomas W.; Omer, Charles A.; Poondru, Srinivasu; Theoclitou, Maria-Elena; Tyurin, Boris; Zinda, Michael J. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 697 - 700

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Citation Number: 20

Abstract

Solid tumors comprise a number of cell types in addition to malignant cells, including macrophages. These tumor-associated macrophages (TAMs) are believed to play a number of roles to promote tumor progression and metastasis. 1 Upon recruitment to the tumor environment, macrophages release pro-angiogenic factors such as VEGF, proteases important for invasion, and other growth factors involved in the growth and motility of tumor cells ...