Tetrahedron Letters

On the stereochemistry of palmerolide A

MD Lebar, BJ Baker

Index: Lebar, Matthew D.; Baker, Bill J. Tetrahedron Letters, 2007 , vol. 48, # 45 p. 8009 - 8010

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Citation Number: 34

Abstract

As part of our program to investigate the chemical diversity of cold-water marine organisms, 1 we recently reported the structure of palmerolide A (1). 2 An enamide-bearing macrolide isolated from the Antarctic tunicate Synoicum adareanum, palmerolide A is a potent inhibitor (2 nM) of vacuolar-ATPase (V-ATPase). In the National Cancer Institute's 60 cell line panel, palmerolide A displays potent and selective cytotoxicity toward melanoma and cytostatic activity ...