Abstract Prostacyclin is involved in many pathological conditions, such as sensitization of inflammation induced pain and isovolumetic distention. Therefore, antagonism of prostacyclin action may be useful in the alleviation of these conditions. In this study, novel potent prostacyclin antagonists, 2-[4-(imidazolin-2-ylideneamino) benzyl]-indan-1-ones were synthesized from their respective substituted indanones in three steps. The ...
