The regiocontrolled preparation of triarylisothiazoles is presented. 3-Halo-5- phenylisothiazole-4-carbonitriles, 1 (hal= Cl) and 18 (hal= I), are converted into the corresponding 4-bromo derivatives 5 (3-hal= Cl) and 24 (3-hal= I) via a Hunsdiecker strategy while the 4-iodo analogues 7 (3-hal= Cl) and 22 (3-hal= I) are prepared via a Hoffmann and Sandmeyer strategy. Regioselective Suzuki, Stille and Negishi reactions ...
