Bioorganic & medicinal chemistry letters

Synthesis of probes for the active site of leucine dehydrogenase

A Sutherland, CL Willis

Index: Sutherland, Andrew; Willis, Christine L. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 1941 - 1944

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Citation Number: 6

Abstract

A series of novel 3-substituted 2-oxobutanoic acids were prepared and incubated with leucine dehydrogenase giving in one case both a kinetic resolution at C-3 and reductive amination of the ketone. This is the first example of an amino acid dehydrogenase catalysed kinetic resolution and reductive amination.