e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Amino acids in the synthesis of heterocyclic systems. The synthesis of 4??oxo??4H??pyrido [1, 2??a] pyridines and 4??oxo??4H??pyrido [1, 2??a] pyrimidines
Abstract The pyridine and quinoline derivatives 2, 3, and 6 with an activated methylene group atα-position in respect to the ring nitrogen atom were converted with 1, 8, or 9 into fused pyrido [1, 2-a] pyridine derivatives 4, 5, 7, and 10. In an analogous manner were the aminopyridines 16 and 17 transformed with thiazolone 9 into pyrido [1, 2-a] pyrimidine derivatives 20, 21, 25, and 26.