Synthesis and antihyperglycemic evaluation of new 2, 4-thiazolidinediones having biodynamic aryl sulfonylurea moieties

DV Jawale, UR Pratap, N Rahuja, AK Srivastava…

Index: Jawale, Dhanaji V.; Pratap, Umesh R.; Rahuja, Neha; Srivastava, Arvind K.; Mane, Ramrao A. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 436 - 439

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Citation Number: 16

Abstract

New 2, 4-thiazolidinediones with aryl sulfonylurea moieties 8a–h have been synthesized by condensing various substituted sulfonamides and 5-(isocyanatomethyl) thiazolidino-2, 4- dione 6. The isocyanomethyl thiazolidinedione was obtained by using the Curtius rearrangement, starting from known 2, 4-dioxo-5-thiazolidineacetic acid 4. The newly synthesized compounds 8a–h have been evaluated for the antihyperglycemic activity in ...