Abstract: Three new 1, 3, 4-oxadiazole, 1, 3-thiazolidine and 1, 2, 4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1, 2, 4-triazole compound was converted to the corresponding Mannich bases using several secondary amines including piperidine, piperazine, morpholine or thiomorpholine moiety. The synthesis of 5-(furan-2-yl)- 4-{[(4-methoxyphenyl) methylidene] amino}-4H-1, 2, 4-triazole-3-thiol (XIII) was performed ...