Solution and fluorescence properties of symmetric dipicolylamine-containing dichlorofluorescein-based Zn2+ sensors

BA Wong, S Friedle, SJ Lippard

Index: Wong, Brian A.; Friedle, Simone; Lippard, Stephen J. Journal of the American Chemical Society, 2009 , vol. 131, p. 7142 - 7152

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Citation Number: 102

Abstract

The mechanism by which dipicolylamine (DPA) chelate-appended fluorophores respond to zinc was investigated by the synthesis and study of five new analogues of the 2′, 7′- dichlorofluorescein-based Zn2+ sensor Zinpyr-1 (ZP1). With the use of absorption and emission spectroscopy in combination with potentiometric titrations, a detailed molecular picture has emerged of the Zn2+ and H+ binding properties of the ZP1 family of sensors. ...