Suzuki cross-coupling approaches to the synthesis of bioactive 3-substituted and 5-substituted-4-methoxy-6-methyl-2-pyrones

LR Marrison, JM Dickinson, IJS Fairlamb

Index: Marrison, Lester R.; Dickinson, Julia M.; Fairlamb, Ian J.S. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 16 p. 2667 - 2671

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Citation Number: 38

Abstract

Suzuki cross-coupling has been used to access a wide range of 3-and 5-substituted 2- pyrones, which show remarkable inhibitory activity against bacteria, yeasts and fungi. 3- Octenyl and 5-octenyl 2-pyrones inhibit human ovarium carcinoma (A2780) and human chronic myelogenous leukaemia (K562) cell lines at the micromolar level.