Abstract A new series of 2, 8-disubstituted-2, 8-diazaspiro [4, 5] decan-1-ones 2 has been synthesized and tested for affinity towards muscarinic receptors by binding studies in comparison with the model RS-86. The membrane phosphatidylinositol turnover in the presence or absence of carbachol has also been investigated. In both experiments all the new derivatives 2 were found to be less active than the model; only 5g, which retains the ...
![2,8-Diazaspiro[4.5]decane-1,3-dione,2-ethyl-8-methyl- Structure](https://image.chemsrc.com/caspic/109/3576-73-6.png)