Pd-Catalyzed Reduction of Aldehydes to Alcohols Using Formic Acid as the Hydrogen Donor

A Wang, Z Yang, J Liu, Q Gui, X Chen…

Index: Wang, Anwei; Yang, Zhiyong; Liu, Jidan; Gui, Qingwen; Chen, Xiang; Tan, Ze; Shi, Ji-Cheng Synthetic Communications, 2014 , vol. 44, # 2 p. 280 - 288

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Abstract

Facile and selective reduction of aromatic aldehydes as well as aliphatic aldehydes to alcohols was achieved using formic acid as the hydrogen donor in the presence of a catalytic amount of Pd(OAc) 2 and Cy 3 P. It was found that both hydrogen atoms in the formic acid molecule can serve as the hydride source. ... [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free ...