Tetrahedron letters

Uncatalyzed condensation between aryl-1, 2-diamines and diethyl bromomalonate: a one-pot access to substituted ethyl 3-hydroxyquinoxaline-2-carboxylates

P Haldar, B Dutta, J Guin, JK Ray

Index: Haldar, Pranab; Dutta, Bishnupada; Guin, Joyram; Ray, Jayanta K. Tetrahedron Letters, 2007 , vol. 48, # 33 p. 5855 - 5857

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Citation Number: 25

Abstract

2,3-Disubstituted quinoxalines are usually synthesized by condensation of aryl-1,2-diamines with epoxides 12 or α-dicarbonyl compounds or their equivalents. 13 Difunctional quinoxalines can also be prepared by cyclization of α-aryliminooximes of α-dicarbonyl compounds 14 and by POCl 3 mediated hetero-annulation of α-nitroketene N,S-anilinoacetals. 15 Very recently, while this manuscript was being prepared, a report appeared describing an efficient ...