Synthesis of F-alkyl α-hydroxy acids and esters from F-alkyl epoxides and F-alkyl α-bromo acids and esters from F-alkyl bromohydrins

AO Amanetoullah, MM Chaabouni, A Baklouti

Index: Ould Amanetoullah; Chaabouni; Baklouti Journal of Fluorine Chemistry, 1997 , vol. 84, # 2 p. 149 - 153

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Citation Number: 5

Abstract

F-alkyl α-hydroxy acids and F-alkyl α-bromo acids were prepared respectively by the nitric acid ring-opening oxidative reaction of F-alkyl oxiranes, and oxidation by chromic acid of F- alkyl bromohydrins. The synthesized acids were converted to the corresponding methyl esters which may prove to be useful in the synthesis of F-alkylated heterocycles.