Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: part I

…, D Song, B Lee, WJ Ko, SK Park, M Won, K Lee…

Index: Yang, Jee Sun; Song, Doona; Lee, Boah; Ko, Won Jin; Park, Song-Kyu; Won, Misun; Lee, Kiho; Kim, Hwan Mook; Han, Gyoonhee European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 2861 - 2866

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Citation Number: 14

Abstract

Abstract We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B,(RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, ...