Synthesis and Cytotoxicity of 2-Methyl-1-substituted-imidazo [4, 5-g] quinoline-4, 9-dione and 7, 8-dihydro-10H-[1, 4] oxazino [3′, 4′: 2, 3] imidazo [4, 5-g] quinoline- …

ME Suh, MJ Kang, HW Yoo, SY Park, CO Lee

Index: Suh, Myung-Eun; Kang, Min-Jung; Yoo, Hee-Won; Park, So-Young; Lee, Chong-Ock Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 2079 - 2083

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Citation Number: 22

Abstract

2-Methyl-1-substituted-imidazo [4, 5-g] quinoline-4, 9-diones and 7, 8-dihydro-10H-[1, 4] oxazino-[3′, 4′: 2, 3] imidazo [4, 5-g] quinoline-5, 12-dione (19) derivatives have been synthesized from 6, 7-dichloro-5, 8-quinolinedione for developing the new anticancer drugs. Our study on the cytotoxicity of imidazoquinolinedione derivatives has revealed that 7, 8- dihydro-10H-[1, 4] oxazino-[3′, 4′: 2, 3] imidazo [4, 5-g] quinoline-5, 12-dione (19), a ...