Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4, 6-Dehydratase

…, YJ Kim, S Caille, M Achmatowicz, O Thiel…

Index: Thiel, Oliver R.; Achmatowicz, Michal M. Organic Syntheses, 2013 , vol. 90, p. 287 - 300

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Abstract

The efficacy of therapeutic antibodies that induce antibody-dependent cellular cytotoxicity can be improved by reduced fucosylation. Consequently, fucosylation is a critical product attribute of monoclonal antibodies produced as protein therapeutics. Small molecule

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A mild synthesis of [1, 2, 4] triazolo [4, 3-a] pyridines

[Schmidt, Michael A.; Qian, Xinhua Tetrahedron Letters, 2013 , vol. 54, # 42 p. 5721 - 5726]

Efficient Synthesis of 3-Substituted 1, 2, 4-Triazolo [4, 3-...

[Padalkar, Vikas S.; Patil, Vikas S.; Phatangare, Kiran R.; Umape, Prashant G.; Sekar Synthetic Communications, 2011 , vol. 41, # 6 p. 925 - 938]

The preparation of 3-phenyl [1, 2, 4] triazolo [4, 3-a] pyri...

[Ito, Suketaka; Kakehi, Akikazu; Matsuno, Toshiyuki; Yoshida, Jun-ichi Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 7 p. 2007 - 2011]