Cardioselective Anti-Ischemic ATP-Sensitive Potassium Channel Openers. 3. Structure-Activity Studies on Benzopyranyl Cyanoguanidines; Modification of the …

…, SZ Ahmed, PG Sleph, S Dzwonczyk…

Index: Atwal, Karnail S.; Grover, Gary J.; Ahmed, Syed Z.; Sleph, Paul G.; Dzwonczyk, Steven; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3236 - 3245

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Citation Number: 27

Abstract

Structure-activity relationships for the cyanoguanidine portion of the lead cardiac selective ATP-sensitive potassium channel (KATP) opener (3) are described. The cyanoguanidine moity appears to be optimal since increasing or decreasing the distance between the aniline nitrogen and the pendant aromatic ring attenuates anti-ischemic potency/selectivity. Similarly, unfavorable results are obtained by replacement of the aniline nitrogen with ...