Inhibitory effect of novel tetrahydropyrimidine-2 (1H)-thiones on melanogenesis

P Thanigaimalai, KC Lee, SC Bang, JH Lee…

Index: Thanigaimalai; Lee, Ki-Cheul; Bang, Seong-Cheol; Lee, Jee-Hyun; Yun, Cheong-Yong; Roh, Eunmiri; Hwang, Bang-Yeon; Kim, Youngsoo; Jung, Sang-Hun Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 3 p. 1135 - 1142

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Citation Number: 19

Abstract

The series of imidazoldine-2-thiones 2 and tetrahydropyrimidine-2-thiones 3 were discovered as inhibitor of α-MSH-induced melanin production in melanoma B16 cells. The primary bioassay showed that 1-(4-ethylbenzyl)-tetrahydropyrimidine-2 (1H)-thione 3e (> 100% inhibition at 10μM, IC50= 1.2 μM) and 1-(4-tert-butylbenzyl)-tetrahydropyrimidine-2 (1H)-thione 3f (> 100% inhibition at 10μM, IC50= 0.76 μM) exhibited potent inhibitory ...