Medicinal chemistry research

Synthesis and anti-congestive heart failure activity of novel levosimendan analogues

L Wang, H Zhou, B Yang, Z Chen, H Yang

Index: Wang, Lisheng; Zhou, Hongxiang; Yang, Bin; Chen, Zhigang; Yang, Hua Medicinal Chemistry Research, 2011 , vol. 20, # 3 p. 287 - 292

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Abstract

Abstract A series of levosimendan analogues were designed and synthesized, employing the Friedel–Crafts reaction, hydrolysis, and cyclization from the key intermediate compound R (−)-6-(4-aminophenyl)-5-methyl-4, 5-dihydro-3 (2H)-pyridazinone, which was obtained from the starting material, acetanilide. These compounds, except 1b, exhibited potent anti- congestive heart failure activities, especially the compounds 1e and 1k, which showed ...