Ring??opening and a novel ring expansion in the reactions of 1??Alkyl??2??carbomethoxyazetidine with hydrazine

HK Leung, BA Phillips…

Index: Leung,H.-K. et al. Journal of Heterocyclic Chemistry, 1976 , vol. 13, p. 247 - 252

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Abstract

Abstract The mechanism of the reactions of 1-t-butyl-2-carbomethoxyazelidine and 1-benzyl- 2-carbomethoxyazetidine with hydrazine hydrate was investigated. Treatment of 1-alkyl-2- earbomethoxyazetidine with hydrazine hydrate in cold ethanol yielded 1-alkylazetidine-2- carhohydrazide. Depending on the sterie bulkiness of the alkyl group of the amino functionality, reactions of 1-alkylazetidine-2-carbohydrazides in methanol gave the ...