Abstract An efficient and flexible asymmetric synthesis of various protected anti-1, 2-sulfanyl amines bearing two adjacent stereogenic centres is described. Key steps are the diastereoselective α-alkylation of α-sulfanylated acetaldehyde-SAMP-hydrazones with various electrophiles and subsequent nucleophilic 1, 2-addition of organocerium reagents to the hydrazone CN double bond. The resulting hydrazines were converted into the title ...
