Synthesis of 2??[(2??chloro??2′??[18F] fluoroethyl) amino]??2H??1, 3, 2??oxazaphosphorinane??2??oxide (18F??fluorocyclophosphamide), a potential tracer for breast tumor …

…, J Czernin, WP Melega, DHS Silverman

Index: Lacan, Goran; Kesner, Amanda L.; Gangloff, Anne; Zheng, Lei; Czernin, Johannes; Melega, William P.; Silverman, Daniel H. S. Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 9 p. 635 - 643

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Citation Number: 7

Abstract

Abstract A fluorine-18 labeled analog of the widely used chemotherapeutic agent cyclophosphamide was synthesized as a tracer for prognostic imaging with positron emission tomography. 2-[(2-Chloro-2′-[18 F] fluoroethyl) amino]-2H-1, 3, 2- oxazaphosphorinane-2-oxide (18 F-fluorocyclophosphamide), was prepared by direct halogen exchange reaction from the parent cyclophosphamide. In small-scale syntheses, ...