Synthesis and antimicrobial activity of bisphosphonates

…, KR Reddy, CB Reddy, B Siva Kumar…

Index: Reddy, M.Veera Narayana; Reddy, K.R. Kishore Kumar; Reddy, C.Bhupendra; Kumar, B.Siva; Reddy, C.Suresh; Reddy, C.Devendranath Journal of Chemical Research, 2009 , # 4 p. 258 - 260

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Citation Number: 6

Abstract

Dimethyl [(substitutedphenyl)(6-oxo6λ5dibenzo [d, f][1, 3, 2] dioxaphophepin-6-yl) methyl] phosphonates (5a–j) were synthesised through a three step process involving preparation of dimethyl hydroxy (substitutedphenyl) methylphosphonates (4a–j) and their reaction with 6- bromodibenzo [d, f][1, 3, 2] dioxaphosphepine (2) in dry toluene in the presence of triethylamine at 50–60° C. Tetramethylguanidine (TMG) as a catalyst was found to ...